Moringa oleifera Leaf Extract Alleviates AFB1-Induced Hepatotoxicity and Oxidative Stress Through the PPARγ/Nrf2 Signaling Pathway.

This animal study investigated whether moringa leaf extract could protect against liver damage caused by aflatoxin B1 (AFB1), a dangerous toxin found in contaminated crops. Researchers used mouse liver tissue and liver cells to test the protective effects. The study found that moringa leaf extract significantly reduced liver damage markers and oxidative stress caused by AFB1 exposure. The extract worked by activating specific cellular pathways (PPAR-gamma and Nrf2) that help cells defend against toxic damage. Key protective compounds identified included naringenin, quercetin, and luteolin. The extract enhanced the body's natural antioxidant systems and reduced harmful reactive oxygen species. Network analysis revealed 50 bioactive components in the moringa extract that could interact with 78 targets related to AFB1 toxicity. The research suggests moringa leaf extract may offer protection against aflatoxin-induced liver damage through multiple molecular mechanisms, though human studies would be needed to confirm these effects.