Effect of Moringa oleifera on inflammatory diseases: an umbrella review of 26 systematic reviews

This comprehensive umbrella review examined 26 systematic reviews to evaluate the evidence for Moringa oleifera's effects on inflammatory diseases. Research suggests that moringa demonstrates anti-inflammatory properties through multiple molecular pathways, particularly targeting NF-κB and Nrf2 signaling pathways while modulating inflammasome activity. The analysis indicates promising therapeutic potential for various inflammatory conditions, though translation to clinical practice remains limited. Studies suggest moringa's bioactive compounds may help reduce inflammatory markers and provide therapeutic benefits across different inflammatory disease states. However, the review highlighted significant gaps in high-quality clinical evidence, with most systematic reviews noting a scarcity of well-designed randomized controlled trials. The lack of standardized preparations and absence of pharmacopoeial monographs for moringa products presents additional challenges for clinical application. While preclinical and some clinical studies indicate anti-inflammatory effects, researchers emphasize the need for more rigorous clinical trials with standardized dosing protocols and preparation methods to establish definitive therapeutic recommendations for inflammatory diseases.