Biological properties of Moringa oleifera: A systematic review of the last decade

This comprehensive systematic review examined 156 studies published over the last decade to evaluate the biological properties of Moringa oleifera. The Colombian research team analyzed evidence across multiple therapeutic areas, finding consistent support for moringa's anticancer, antimicrobial, antidiabetic, and anti-inflammatory properties. The review highlighted moringa's potential in addressing two critical global health challenges: cancer treatment and antimicrobial resistance. Studies indicated that moringa compounds can induce cancer cell death through p53 pathway activation and NF-κB inhibition, while also demonstrating effectiveness against drug-resistant bacterial and fungal pathogens. The antidiabetic effects were supported by evidence of improved glucose metabolism and insulin sensitivity. Anti-inflammatory properties were documented through reduced inflammatory marker levels across various study models. The review encompassed research from multiple countries and included various study designs from laboratory investigations to clinical trials. However, the authors noted that most evidence remains at the preclinical stage, with limited large-scale human studies available. The findings suggest moringa's therapeutic potential spans multiple health conditions, but emphasized the need for more robust clinical evidence to support therapeutic applications.