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Effects of Moringa oleifera leaf extract on glycemic control and inflammation in metabolic syndrome: a randomized controlled trial

Mahdieh Abbasalizad Farhangi, Leila Nikniaz, Zeinab Nikniaz

ScienceDirect2 December 2025
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Mahdieh Abbasalizad Farhangi, Leila Nikniaz, Zeinab Nikniaz (2025). Effects of Moringa oleifera leaf extract on glycemic control and inflammation in metabolic syndrome: a randomized controlled trial. ScienceDirect.

This randomized controlled trial investigated whether Moringa oleifera leaf extract could help manage blood sugar and inflammation in people with metabolic syndrome. Seventy-three Iranian adults with metabolic syndrome were randomly assigned to receive either 1000mg of moringa leaf extract twice daily or a placebo for 8 weeks. The study found significant improvements in key blood sugar markers among those taking moringa extract. Participants in the moringa group showed meaningful reductions in HbA1c levels, which reflects average blood sugar over 2-3 months, and improvements in insulin levels compared to the placebo group. These findings suggest that moringa leaf extract may help support healthy blood sugar management in people with metabolic syndrome. Metabolic syndrome is a cluster of conditions including high blood pressure, elevated blood sugar, excess abdominal fat, and abnormal cholesterol levels that increase the risk of heart disease and diabetes. The study adds to growing research indicating that moringa may have beneficial effects on glucose metabolism and could potentially serve as a complementary approach for managing metabolic health, though more research is needed to confirm long-term effects and optimal dosing.

Study details

Sample size

73 — metabolic syndrome patients

Duration

56 days

Plant part

Leaf

Preparation

Extract Other

Dosage

2000 mg (1000mg twice daily)

Country

Iran

Dosage protocol

2000mg daily total dose, administered as 1000mg twice daily, standardized leaf extract in capsule form, taken for 8 weeks

Key compounds

quercetinkaempferolchlorogenic acidisothiocyanatesbeta-carotene

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