Overview of the Effects of Moringa oleifera Leaf Extract on Oxidative Stress and Male Infertility: A Review

This systematic review examined research on Moringa oleifera leaf extract's potential effects on male fertility and oxidative stress. The authors analyzed 25 studies to understand how moringa might help address male infertility through its antioxidant properties. Male infertility affects approximately 15% of couples worldwide, with oxidative stress being a major contributing factor that damages sperm and disrupts reproductive function. The review found that moringa leaf extract contains powerful antioxidant compounds that research suggests may help protect against oxidative damage in the male reproductive system. Studies indicated potential benefits for sperm quality, including improvements in sperm count, motility, and morphology. The extract also showed promise for supporting healthy testosterone levels and protecting testicular tissue from oxidative damage. Most evidence came from animal studies, with limited human clinical trials available. The researchers noted that moringa's high content of vitamins C and E, flavonoids, and other bioactive compounds likely contribute to its antioxidant effects. While results appear promising, the authors emphasized that more human studies are needed to confirm these potential benefits and establish optimal dosing protocols for men with fertility concerns.