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Effects of Moringa oleifera leaves on the blood glucose, blood pressure, and lipid profile of type 2 diabetic subjects: A parallel group randomized clinical trial of efficacy

Afiaenyi IC, Ngwu EK, Okafor AM, Ayogu RN

Nutrition & Health (SAGE)1 March 2025
52
Preliminary
RctPositiveBlood SugarBlood Pressure

Afiaenyi IC, Ngwu EK, Okafor AM et al. (2025). Effects of Moringa oleifera leaves on the blood glucose, blood pressure, and lipid profile of type 2 diabetic subjects: A parallel group randomized clinical trial of efficacy. Nutrition & Health (SAGE).

This Nigerian clinical trial examined how fresh Moringa oleifera leaves affect blood sugar, blood pressure, and cholesterol levels in people with type 2 diabetes. Forty diabetic participants were randomly assigned to receive different amounts of fresh moringa leaves daily (20g, 40g, or 60g) for two weeks. Research suggests that the 40g dose group experienced significant improvements in blood pressure, with systolic pressure dropping from 136 to 124 mmHg (p=0.01). However, fasting blood glucose levels did not show significant changes across any of the dosage groups during the short study period. The study used fresh moringa leaves rather than processed extracts or powders, which may provide different bioactive compound profiles compared to dried preparations. This approach represents a more practical application for communities with access to fresh moringa plants. The research indicates that moderate doses of fresh moringa leaves may offer cardiovascular benefits for diabetic patients, particularly in blood pressure management. The lack of significant glucose changes might be attributed to the short duration of the intervention or the specific preparation method used.

Study details

Sample size

40 — 40 type 2 diabetic subjects

Duration

14 days

Plant part

Leaf

Preparation

Fresh

Dosage

20000 mg (20g, 40g, or 60g fresh leaves daily)

Country

Nigeria

Dosage protocol

20g, 40g, or 60g fresh moringa leaves daily for 14 days, with 40g showing optimal blood pressure benefits

Key compounds

quercetinkaempferolchlorogenic acidisothiocyanatesniazimicin

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